منابع مشابه
Macrolides in dermatology
Erythromycin was the first macolide discovered in 1952. In 1990s new macrolides including clarithromycin, azithromycin, and dirithromycin were introduced to the market. We provide a review of their structure, pharmacokinetics, mechanisms of action, and indications in dermatology.
متن کاملAzithromycin is more allergenic than clarithromycin in children with suspected hypersensitivity reaction to macrolides.
BACKGROUND Macrolides are considered safe antibiotics with reduced allergenic activity. However, studies on the safety of macrolides are scarce, particularly in children. OBJECTIVE The aim of this study was to assess the frequency of hypersensitivity reactions to clarithromycin and azithromycin in a group of children referred to our allergy unit for suspected macrolide allergy. METHODS We r...
متن کاملMethacholine and Macrolides
study are relevant, I believe that the design of the study was not adequate to answer these questions. First, all patients were on NM for w3 months and one patient even for 70 months, whereas they trained only for 1 day on FFM. In our centre (Dept of Pulmonary Diseases/ Home mechanical ventilation, University Hospital Groningen, Groningen, The Netherlands), patients routinely need more time (y7...
متن کاملCombination antibiotic therapy with macrolides in community-acquired pneumonia: more smoke but is there any fire?
F or an extremely common disease, the optimal therapy of community-acquired pneumonia (CAP) remains surprisingly controversial. A good example of the differences in opinion is the contrast between the recent guidelines of the American1 and British2 thoracic societies with respect to their recommendations on classification of severity and choice of empiric antibiotics. Several retrospective stud...
متن کاملMacrolides: pharmacokinetics and pharmacodynamics.
Three pharmacokinetic/pharmacodynamic parameters--(i) the peak concentration to the minimum inhibitory concentration ratio (C(max)/MIC); (ii) the area under the concentration-time curve to MIC ratio (AUC(24h)/MIC); and (iii) the time the concentration exceeds the MIC (T>MIC)--are important predictors of the clinical efficacy of antibiotics. For antibiotics with pronounced concentration-dependen...
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ژورنال
عنوان ژورنال: BMJ
سال: 1991
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.303.6803.594